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Photo of Frances Arnold

Frances Arnold

Linus Pauling Professor
Chemical Engineering
Bioengineering and Biochemistry
Caltech
Phone:
+1 626-395-4162
Email:
frances@cheme.caltech.edu
Website:
Website
Twitter Link:
@francesarnold

Research Focus Areas

Research Interests

Development and implementation of powerful methods of laboratory evolution to solve complex design problems, with specific applications in renewable energy, drug discovery and development, and production of chemicals. Combining computational and evolutionary design approaches to create enzymes and microbial catalysts for converting cellulosic biomass to fuels and chemicals.

Distinguished Awards

2018 Nobel Prize in Chemistry
2016 Millennium Technology Prize
2013 National Medal of Technology and Innovation
2011 Draper Prize in Engineering

National Academies 

NAE 2000, NAM 2004, NAS 2008, NAI 2016

News

Displaying 1 - 20 of 33

ICB Supported Publications

MicroED structure of a protoglobin reactive carbene intermediate

Emma Danelius, Nicholas J. Porter, Johan Unge, Frances H. Arnold, Tamir Gonen
bioRxiv,
10.1101/2022.10.18.512604

Biocatalytic Carbene Transfer Using Diazirines

Nicholas J. Porter, Emma Danelius, Tamir Gonen, and Frances H. Arnold
Journal of the American Chemical Society,
10.1021/jacs.2c02723

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement

David C. Miller, Ravi G. Lal, Luca A. Marchetti, and Frances H. Arnold
Journal of the American Chemical Society,
10.1021/jacs.2c00251

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective

David C. Miller, Ravi G. Lal, Luca A. Marchetti and Frances H. Arnold
ChemRxiv,
10.26434/chemrxiv-2021-8fq9b-v3

Combining chemistry and protein engineering for new-to-nature biocatalysis

David C. Miller, Soumitra V. Athavale and Frances H. Arnold
Nature Synthesis,
10.1038/s44160-021-00008-x

Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation

Zhen Liu, Carla Calvó-Tusell, Andrew Z. Zhou, Kai Chen, Marc Garcia-Borràs and Frances H. Arnold
Nature Chemistry,
10.1038/s41557-021-00794-z

Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer

Yang Yang and Frances H. Arnold
Accounts of Chemical Research,
10.1021/acs.accounts.0c00591

New-to-nature chemistry from old protein machinery: carbene and nitrene transferases

Zhen Liu and Frances H. Arnold
Current Opinion in Biotechnology,
10.1016/j.copbio.2020.12.005

High throughput screening with SAMDI mass spectrometry for directed evolution

Adam J. Pluchinsky, Daniel J. Wackelin, Xiongyi Huang, Frances H. Arnold, Milan Mrksich
Journal of the American Chemical Society,
10.1021/jacs.0c07828

Nature’s Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases

Noah P. Dunham and Frances H. Arnold
ACS Catalysis,
10.1021/acscatal.0c03606

Enzymatic lactone-carbene C-H insertion to build contiguous chiral centers

Andrew Z. Zhou, Kai Chen, and Frances H. Arnold
ACS Catalysis,
10.1021/acscatal.0c01349

Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes

Kai Chen and Frances H. Arnold
Journal of the American Chemical Society,
10.1021/jacs.0c01313

Engineering new catalytic activities in enzymes

Kai Chen and Frances H. Arnold
Nature Catalysis,
10.1038/s41929-019-0385-5

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics

Claire N. Bedbrook, Kevin K. Yang, J. Elliott Robinson, Elisha D. Mackey, Viviana Gradinaru, and Frances H. Arnold
Nature Methods,
10.1038/s41592-019-0583-8

Machine-learning-guided directed evolution for protein engineering

Kevin K. Yang, Zachary Wu, and Frances H. Arnold
Nature Methods,
10.1038/s41592-019-0496-6

Learned protein embeddings for machine learning

Kevin K. Yang, Zachary Wu, Claire N. Bedbrook and Frances H. Arnold
Bioinformatics,
10.1093/bioinformatics/bty178

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization

Claire N. Bedbrook, Kevin K. Yang, Austin J. Rice, Viviana Gradinaru and Frances H. Arnold
PLOS Computational Biology,
10.1371/journal.pcbi.1005786

Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore

Herwig, L., Rice, A.J., Bedbrook, C.N., Zhang, R.K., Lignell, A., Cahn, J.K.B., Renata, H., Dodani, S.C., Cho, I., Cai, L., Gradinaru, V. and Arnold, F.H.
Cell Chemical Biology,
10.1016/j.chembiol.2017.02.008

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsin

Bedbrook, C.N., Rice, A.J., Yang, K.K., Ding, X., Chen, S., LeProust, E.M., Gradinaru, V. and Arnold, F.H.
Proceedings of the National Academy of Sciences ,
10.1073/pnas.1700269114

Recent advances in engineering microbial rhodopsins for optogenetics

R. Scott McIsaac, Claire N. Bedbrook, and Frances H. Arnold
Current Opinion in Structural Biology,
10.1016/j.sbi.2015.05.001
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