Forest M. White

CONTACT
Building 56-787a
Massachusetts Institute of Technology
Cambridge, MA 02139

Tel.: 617-258-8949
Email: fwhite@mit.edu
Web site: http://web.mit.edu/fwhitelab/

EDUCATION
Ph.D: 1997, Florida State University
B.S.: 1993, Framingham State College

RESEARCH INTERESTS
The goal of research in the White lab is to understand how protein phosphorylation-mediated signaling networks drive biological responses to cellular stimulation. If we take a cue-signal-response view of biological systems, we can present the systems with different cues, such as agonists or antagonists, over-expression, mutation, or knock-down of components in the network and monitor biological responses including proliferation, cell motility, endocytosis, and invasiveness. Quantification of the signaling networks which result from each of these cues and drive the corresponding biological response should provide key information regarding the mechanism by which the cue relates to the response. A protein may have multiple phosphorylation sites which control different biological functions and show unique phosphorylation dynamics. A site-specific high-resolution map of the signaling network, with associated temporal dynamics, will enable improved computational modeling of the systems and provide predictive power for more effective targeted interventions in aberrant signaling networks.

CURRENT TEAMS

This researcher is currently not associated with a team.