Frances H Arnold

2018 Nobel Prize in Chemistry
2016 Millennium Technology Prize
2013 National Medal of Technology and Innovation
2011 Draper Prize in Engineering
Linus Pauling Professor

Chemical Engineering, Bioengineering and Biochemistry

Caltech

Phone:

626-395-4162

Email:

frances@cheme.caltech.edu

Website:

http://www.che.caltech.edu/groups/fha/index.html

Research Interests:

Development and implementation of powerful methods of laboratory evolution to solve complex design problems, with specific applications in renewable energy, drug discovery and development, and production of chemicals. Combining computational and evolutionary design approaches to create enzymes and microbial catalysts for converting cellulosic biomass to fuels and chemicals.

Special Distinction:

NAE 2000, NAM 2004, NAS 2008, NAI 2016

ICB Task Orders:

Biotechnology Tools

ICB-Supported Publications:

Learned protein embeddings for machine learning

Kevin K. Yang, Zachary Wu, Claire N. Bedbrook and Frances H. Arnold

Bioinformatics, March, 2018
10.1093/bioinformatics/bty178
Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization

Claire N. Bedbrook, Kevin K. Yang, Austin J. Rice, Viviana Gradinaru and Frances H. Arnold

PLOS Computational Biology, October, 2017
10.1371/journal.pcbi.1005786
Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore

Herwig, L., Rice, A.J., Bedbrook, C.N., Zhang, R.K., Lignell, A., Cahn, J.K.B., Renata, H., Dodani, S.C., Cho, I., Cai, L., Gradinaru, V. and Arnold, F.H.

Cell Chemical Biology, March, 2017
10.1016/j.chembiol.2017.02.008
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsin

Bedbrook, C.N., Rice, A.J., Yang, K.K., Ding, X., Chen, S., LeProust, E.M., Gradinaru, V. and Arnold, F.H.

Proceedings of the National Academy of Sciences , February, 2017
10.1073/pnas.1700269114
Genetically encoded spy ppeptide fusion system to detect plasma membrane-localized proteins in vivo.

Bedbrook, C. N., Kato, M., Kumar, S. R., Lakshmanan, A., Nath, R. D., Sun, F., Sternberg, P. W., Arnold, F. H. and Gradinaru, V.

Chemistry & Biology, July, 2015
10.1016/j.chembiol.2015.06.020
Directed evolution of Gloeobacter violaceus rhodopsin spectral properties

M. K. M. Engqvist, R. S. McIsaac, P. Dollinger, N. C. Flytzanis, M. Abrams, S. Schor, and F. H. Arnold

Journal of Molecular Biology, January, 2015
10.1016/j.jmb.2014.06.015
Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures

D. L. Trudeau, T. M. Lee, and F. H. Arnold

BIotechnology and Bioengineering, December, 2014
10.1002/bit.25308
Directed evolution of a far-red fluorescent rhodopsin

R. S. McIsaac, M. K. M. Engqvist, T. Wannier, A. Z. Rosenthal, L. Herwig, N. C. Flytzanis, E. S. Imasheva, J. K. Lanyi, S. P. Balashov, V. Gradinaru, and F. H. Arnold

PNAS, September, 2014
10.1073/pnas.1413987111
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons

N. C. Flytzanis, C. N. Bedbrook, H. Chiu, M. K. M. Engqvist, C. Xiao, K Y. Chan, P W. Sternberg, F. H. Arnold, and V. Gradinaru

Nature Communications, September, 2014
10.1038/ncomms5894
Innovation by homologous recombination

D. L. Trudeau, M. A. Smith, and F. H. Arnold

Curr. Opin. Chem. Biol., December, 2013
10.1016/j.cbpa.2013.10.007
Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination

M. A. Smith, C. N. Bedbrook, T. Wu, and F. H. Arnold

ACS Synth. Biol., December, 2013
10.1021/sb400010m
PNAS Plus: Navigating the protein fitness landscape with Gaussian processes

P. A. Romero, A. Krause, and F. H. Arnold

Proceedings of the National Academy of Sciences, January, 2013
10.1073/pnas.1215251110
Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods

R. S. Komor, P. A. Romero, C. B. Xie, and F. H. Arnold

Protein Engineering Design and Selection, November, 2012
10.1093/protein/gzs058
Random field model reveals structure of the protein recombinational landscape

P. A. Romero and F. H. Arnold

PLoS Computational Biology, October, 2012
10.1371/journal.pcbi.1002713
SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis

P. Romero, E. Stone, C. Lamb, L. Chantranupong, A. Krause, A. Miklos, R. Hughes, B. Fechtel, A. Ellington, F. Arnold, and G. Georgiou

ACS Synthetic Biology, March, 2012
10.1021/sb300014t
Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination

Heinzelman, P., Komor, R., Kanaan, A., Romero, P., Yu, X., Mohler, S., Snow, C., & Arnold, F. H.

Protein Engineering, Design & Selection, September, 2010
10.1093/protein/gzq063