Batch fabrication of high performance planar patch-clamp devices in quartz

The success of the patch-clamp technique has driven an effort to create wafer-based patch-clamp platforms. We develop a lithographic/electrochemical processing scheme that generates ultrasmooth, high aspect ratio pores in quartz. These devices achieve gigaohm seals in nearly 80% of trials, with the majority exhibiting seal resistances from 20-80 GΩ, competing with pipette-based patch-clamp. 

Nagarah, J., Paek, E., Luo, Y., Wang, P., Hwang, G., Heath, J.
Advanced Materials
Volume: 22
Pages: 4622-4627
Date: September, 2010
ICB Affiliated Authors: James R Heath