Increased ion conductance across mammalian membranes modified with conjugated oligoelectrolytes

Variation in conjugated oligoelectrolyte (COE) repeat units is shown to affect the rate of COE insertion into mammalian membrane patches and membrane patch stabilities. These findings suggest that it is possible to find COE structures that do not destroy membranes while at the same time allow for more facile transmembrane movement of ions/substrates.

J. Du, A. W. Thomas, X. Chen, L. E. Garner, C. A. Vandenberg, and G. C. Bazan
Chem. Commun.
Volume: 49
Number: 83
Pages: 9624–6
Date: October, 2013
ICB Affiliated Authors: Guillermo C Bazan