Label free detection of nucleic acids by modulating nanochannel surfaces

We develop surface-modified 100 nm silica nanofluidic channels that change in measured conductivity upon exposure to single- or double-stranded DNA. Through careful monitoring of both electromigrative and advective current in the channel, we can detect nanomolar concentrations of DNA. These results can be exploited for inexpensive, all-electronic DNA sensors.

P. Crisalli, C. McCallum, and S. Pennathur
Chemical Communications
Volume: 51
Number: 12
Pages: 2335-2338
Date: December, 2014
ICB Affiliated Authors: Sumita Pennathur