Residue-specific incorporation of noncanonical amino acids into proteins: Recent developments and applications

Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we describe recent technical developments and applications of residue-specific incorporation to problems ranging from elucidation of biochemical mechanisms to engineering of protein-based biomaterials. We hope to inform the reader of the ease and broad utility of residue-specific non-canonical amino acid incorporation with the goal of inspiring investigators outside the field to consider applying this tool to their own research.

Johnson, J., Lu, Y., Van Deventer, J., Tirrell, D
Current Opinion in Chemical Biology
Volume: 14
Number: 6
Pages: 774-780
Date: December, 2010
ICB Affiliated Authors: David A Tirrell