Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics

Proteins on film: The Overhauser dynamic nuclear polarization method resolves hydration dynamics to an unprecedented level of detail for a transmembrane protein surface. The heterogeneous hydration landscape of proteorhodopsin rearranges upon photoactivation (see picture), thus providing an insight into how water contributes to protein function even for biological systems embedded in a hydrophobic membrane.

S. Hussain, J. M. Franck, and S. Han
Angewandte Chemie International Edition
Volume: 52
Number: 7
Pages: 1953-1958
Date: February, 2013
ICB Affiliated Authors: Songi Han