In Vivo Systems Biology: Multi-Scale, Multi-Variate Analysis of Inflammatory Pathologies

Presented by: 

Systems Biology and Bioengineering, UCSB

Speaker(s): 

Douglas Lauffenburger
Ford Professor of Bioengineering, MIT
Biological Engineering, Biology and Chemical Engineering

Date: 

October 27, 2014

Time: 

2:00PM to 5:00PM

Location: 

Mosher Alumni Hall, # 1001

Description: 

Professor Douglas Lauffenburger (MIT) will be giving the inaugural Mellichamp lecture in Bioengineering and Systems Biology: In Vivo Systems Biology: Multi-Scale, Multi-Variate Analysis of Inflammatory Pathologies

Abstract: 

Complex diseases such as cancer, arthritis, diabetes, endometriosis, Alzheimer’s, and many others, all involve interactions of tissue cells with immune system cells via molecular communication processes, and resulting disease consequently arises from dysregulated signaling network activities governing pathological cell behaviors.  We are employing combined experimental and computational systems biology approaches to understand these communication and signaling processes at multiple scales, integrating across multiple intracellular pathways, multiple extracellular factors, and multiple cell types, with emphasis on in vivo studies in animal models and human subjects.  This talk will present an overview of our paradigmatic concept, technical approaches, and example applications.

Biography: 

We are employing combined experimental and computational systems biology approaches to understand these communication and signaling processes at multiple scales, integrating across multiple intracellular pathways, multiple extracellular factors, and multiple cell types, with emphasis on in vivo studies in animal models and human subjects.  This talk will present an overview of our paradigmatic concept, technical approaches, and example applications.