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Photo of James Heath

James Heath

Gilloon Professor
Chemistry
Caltech
Phone:
+1 626-395-6079
Email:
heath@caltech.edu
Office:
Mail Code 127-72
Website:
[Add Website Name]

Nanosystems biology, molecular electronics, fundamental nanoscale physics and chemistry. Part of alliance to attack challenges in cancer and immunology and ultra-rapid disease diagnostics by integrating newly developed nanotechnology and microfluidics tools with modern cancer biology and immunology.

Displaying 1 - 15 of 15

ICB Supported Publications

Allosteric Inhibitor of KRas Identified Using a Barcoded Assay Microchip Platform

Amy M. McCarthy, Jungwoo Kim, A. Katrine Museth, Ryan K. Henning, John E. Heath, Emma Winson, Joseph J. Oh, Jingxin Liang, Sunga Hong and James R. Heath
Analytical Chemistry,
10.1021/acs.analchem.8b00706

Modulating the Folding Landscape of Superoxide Dismutase 1 with Targeted Molecular Binders

David N. Bunck, Beatriz Atsavapranee, Anna K. Museth, David VanderVelde and James R. Heath
Angewandte Chemie,
10.1002/ange.201802269

Epitope‐Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin‐17F

Bert T. Lai, Jeré A. Wilson, Jacquie Malette Loredo, Suresh M. Pitram, Nicole A. LaBerge, James R. Heath and Heather D. Agnew
Eurpoean Journal of Chemistry,
10.1002/chem.201704752

Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications

Coppock, M. B., Warner, C. R., Dorsey, B., Orlicki, J. A., Sarkes, D. A., Lai, B. T., Pitram, S. M., Rohde, R. D., Malette, J. and Wilson, J. A. and Kearney, P., Fang, K. C., Law, S. M. and Candelario, S. L., Farrow, B., Finch, A. S., Agnew, H. D., Heath, J. R. and Stratis-Cullum, D. N.
Peptide Science,
10.1002/bip.22934

A general synthetic approach for designing epitope-targeted macrocycle peptide ligands

Das, S., Nag, A., Liang, J. X., Bunck, D. N., Umeda, A., Farrow, B., Coppock, M. B., Sarkes, D. A., Finch, A. S., Agnew, H. D., Pitram, S., Lai, B., Yu, M. B., Museth, A. K., Deyle, K. M., Lepe, B., Rodriquez-Rivera, F.-P., McCarthy, A., Alvarez-Villalonga, B., Chem, A., Heath, J. E., Stratis-Cullum, D. and Heath, J.R.
Angewandte Chemie,
10.1002/anie.201505243

Epitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin

B. Farrow, M. Wong, J. Malette, B. Lai, K. M. Deyle, S. Das, A. Nag, H. D. Agnew, and J. R. Heath
Angewandte Chemie International Edition,
10.1002/anie.201502451

A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1

K. M. Deyle, B. Farrow, Y. Q. Hee, J. Work, M. Wong, B. Lai, A. Umeda, S. W. Millward, A. Nag, Samir Das, and J. R. Heath
Nature Chemistry,
10.1038/nchem.2223

Degradation of Akt using protein-catalyzed capture agents

Henning, R. K., Varghese, J. O., Das, S., Nag, A. Tang, G., Tang, K., Sutherland, A. M. and Heath, J. R.
Journal of Peptide Science,
10.1002/psc.2858

A chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2

A. Nag, S. Das, M. B. Yu, K. M. Deyle, S. W. Millward, and J. R. Heath
Angew. Chemie Int. Ed.,
10.1002/anie.201305882

A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen

B. Farrow, S. A. Hong, E. C. Romero, B. Lai , M. B. Coppock , K. M. Deyle, A. S. Finch , D. N. Stratis-Cullum , H. D. Agnew , S. Yang, and J. R. Heath
ACS Nano,
10.1021/nn404296k

A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera

J. A. Pfeilsticker, A. Umeda, B. Farrow, C. L. Hsueh, K. M. Deyle, J. T. Kim, B. T. Lai, and J. R. Heath
PLoS One,
10.1371/journal.pone.0076224

In situ click chemistry: from small molecule discovery to synthetic antibodies

S. W. Millwar, H. D. Agnew, B. Lai, S. S. Lee, J. Lim, A. Nag, S. Pitram, R. Rohde, and J. R. Heath
Integrative Biology,
10.1039/c2ib20110k

Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1

S. Millward, R. Henning, G. Kwong, S. Pitram, H. Agnew, K. Deyle, A. Nag, J. Hein, S. Lee, J. Lim, J. Pfeilsticker, K. Sharpless, and J. Heath
Journal of the American Chemical Society,
10.1021/ja2064389

Flow optimization study of a batch microfluidics PET tracer synthesizing device

Elizarov, A., Meinhart, C., Miraghaie, R., van Dam, R.M., Huang, J., Daridon, A., Heath, J., Kolb, H.
Biomedical Microdevices,
10.1007/s10544-010-9488-0

Batch fabrication of high performance planar patch-clamp devices in quartz

Nagarah, J., Paek, E., Luo, Y., Wang, P., Hwang, G., Heath, J.
Advanced Materials,
10.1002/adma.201001793
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