Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

Abstract

Targeted cancer therapeutics have demonstrated more limited clinical efficacy than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms have been largely attributed to genetic changes, but a substantial proportion of resistance observations remain unexplained by genomic properties. Emerging evidence shows that receptor tyrosine kinase (RTK) reprogramming is a major alternative process causing targeted drug resistance, separate from genetic alterations. Hence, the contributions of mechanisms leading to this process need to be more rigorously assessed.

ICB Affiliated Authors

Authors
Allison M. Claas, Lyla Atta, Simon Gordonov, Aaron S. Meyer, and Douglas A. Lauffenburger
Date
Type
Peer-Reviewed Article
Journal
Cellular and Molecular Bioengineering
Volume
11
Pages
451–469
Emblems