Photo of Kevin Plaxco

Kevin Plaxco

ICB Biotechnology Tools Co-Leader

Director, Center for Bioengineering

Professor

Chemistry & Biochemistry

UC Santa Barbara

+1 805-893-5558

kwp@chem.ucsb.edu

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We are developing a broad class of optical and electronic (electrochemical) biosensors based on the binding-induced folding of proteins, peptides and DNA. These sensors are sensitive (to femtomolar), specific, rapid (minutes) and selective enough to deploy directly in serum, foodstuffs and other grossly contaminated materials.

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ICB Supported Publications

Quantification of transcription factor binding in cell extracts using an electrochemical, structure-switching biosensor

A. Bonham, K. Hsieh, B. Ferguson, A. Vallée-Bélisle, F. Ricci, H. Soh, and K. Plaxco

Journal of the American Chemical Society, 2012

10.1021/ja2115663

Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches

K. Hsieh, R. White, B. Ferguson, K. Plaxco, Y. Xiao, and H. Soh

Angewandte Chemie International Edition, 2011

10.1002/ange.201103482

Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling

X. Zuo, F. Xia, A. Patterson, H. Soh, Y. Xiao, and K. Plaxco

ChemBioChem, 2011

10.1002/cbic.201100592

An electrochemical supersandwich assay for sensitive and selective DNA detection in complex matrices

Xia, F., White, R., Zuo, X., Patterson, A., Xiao, Y., Kang, D., Gong, X., Plaxco, K., Heeger

Journal of the American Chemical Society, 2010

10.1021/ja104998m

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

Xia, F., Zuo, X., Yang, R., Xiao, Y., Kang, D., Vallée-Bélisle, A., Gong, X., Yuen, J.D., Hsu, B.Y., Heeger, A., Plaxco, K.

Proceedings of the National Academy of Sciences, 2010

10.1073/pnas.1005632107