Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics

Abstract

Proteins on film: The Overhauser dynamic nuclear polarization method resolves hydration dynamics to an unprecedented level of detail for a transmembrane protein surface. The heterogeneous hydration landscape of proteorhodopsin rearranges upon photoactivation (see picture), thus providing an insight into how water contributes to protein function even for biological systems embedded in a hydrophobic membrane.

ICB Affiliated Authors

Authors
S. Hussain, J. M. Franck, and S. Han
Date
Type
Peer-Reviewed Article
Journal
Angewandte Chemie International Edition
Volume
52
Pages
1953-1958
Emblems