For optimization and enhancement of human physiological state and performance, human biology must be understood in terms of computational models, as in all other realms of engineered technologies. A major obstacle in achieving this is the limited ability to undertake experimental perturbations and measurements for humans in vivo, so that generation of models for higher biological systems is more commonly pursued in animal studies. A vital challenge that must consequently be addressed is how to translate observations from experimental animals to human subjects. We will pursue this challenge by aiming to construct and validate an integrated experimental/computational approach for mapping molecule-to-phenotype relationships. We will pursue this challenge along multiple avenues, aiming to develop the most suitable methods for diverse classes of problems.