Systems and Synthetic Biology

Network analysis of functional RNA sequences. Project: Macromolecular Design from Sequence-Activity Analysis.

The ICB Systems and Synthetic Biology task order aims to develop breakthrough methods and to generate new insights for complex cellular operations. Quantitative experimental methods and computational modeling provide new understanding and enable manipulation of cell behaviors in bacterial populations and in mammalian tissues by multi-variate genetic or biochemical modulations. Potential applications of relevance to the Army include tools for analyzing and understanding complex networked systems whose elements are dynamic and stochastic in nature, as well as the development of new technologies for materials production, environmental diagnostics and remediation, and medical diagnostics and therapeutics using engineering biological systems.

Research Projects