Photo of David Tirrell

David Tirrell

Provost and Larson Provostial Chair

McCollum-Corcoran Professor

Chemistry and Chemical Engineering

Caltech

+1 626-395-3140

tirrell@caltech.edu

Research Focus Areas

Research Interests

Combination of organic, biological, and materials chemistry to make new polymeric systems of controlled molecular and supramolecular architectures. Investigation of artificial proteins made by expression of artificial genes in microbial cells, artificial amino acids to engineer proteins with useful properties, and novel methods of biological imaging and proteome-wide investigation of cellular processes.

National Academies

NAS 2006, NAE 2008, NAM 2011, NAI 2018

News

David Tirrell Wins ACS 2019 National Award for Achievement in Biomimetic Chemistry

ICB Caltech Project Leader David Tirrell Named Fellow of the National Academy of Inventors

Congratulations to the ICB’s David Tirrell, Caltech’s New Provost

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ICB Supported Publications

Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition

Szychowski, J., Mahdavi, A., Hodas, J., Bagert, J., Ngo, J., Landgraf, P., Schuman, E.M., Tirrell, D.

Journal of the American Chemical Society, 2010

10.1021/ja1083909

Residue-specific incorporation of noncanonical amino acids into proteins: Recent developments and applications

Johnson, J., Lu, Y., Van Deventer, J., Tirrell, D

Current Opinion in Chemical Biology, 2010

10.1016/j.cbpa.2010.09.013

Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition

Beatty, K., Fisk, J., Smart, B., Lu, Y., Szychowski, J., Hangauer, M., Baskin, J., Bertozzi, C., Tirrell, D.

ChemBioChem, 2010

10.1002/cbic.201000419