1. people
Photo of Frances Arnold

Frances Arnold

Linus Pauling Professor
Chemical Engineering
Bioengineering and Biochemistry
Caltech
Phone:
+1 626-395-4162
Email:
frances@cheme.caltech.edu
Website:
Website
Twitter Link:
@francesarnold

Research Focus Areas

Research Interests

Development and implementation of powerful methods of laboratory evolution to solve complex design problems, with specific applications in renewable energy, drug discovery and development, and production of chemicals. Combining computational and evolutionary design approaches to create enzymes and microbial catalysts for converting cellulosic biomass to fuels and chemicals.

Distinguished Awards

2018 Nobel Prize in Chemistry
2016 Millennium Technology Prize
2013 National Medal of Technology and Innovation
2011 Draper Prize in Engineering

National Academies 

NAE 2000, NAM 2004, NAS 2008, NAI 2016

News

Displaying 21 - 39 of 39

ICB Supported Publications

Machine-learning-guided directed evolution for protein engineering

Kevin K. Yang, Zachary Wu, and Frances H. Arnold
Nature Methods,
10.1038/s41592-019-0496-6

Learned protein embeddings for machine learning

Kevin K. Yang, Zachary Wu, Claire N. Bedbrook and Frances H. Arnold
Bioinformatics,
10.1093/bioinformatics/bty178

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization

Claire N. Bedbrook, Kevin K. Yang, Austin J. Rice, Viviana Gradinaru and Frances H. Arnold
PLOS Computational Biology,
10.1371/journal.pcbi.1005786

Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore

Herwig, L., Rice, A.J., Bedbrook, C.N., Zhang, R.K., Lignell, A., Cahn, J.K.B., Renata, H., Dodani, S.C., Cho, I., Cai, L., Gradinaru, V. and Arnold, F.H.
Cell Chemical Biology,
10.1016/j.chembiol.2017.02.008

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsin

Bedbrook, C.N., Rice, A.J., Yang, K.K., Ding, X., Chen, S., LeProust, E.M., Gradinaru, V. and Arnold, F.H.
Proceedings of the National Academy of Sciences ,
10.1073/pnas.1700269114

Recent advances in engineering microbial rhodopsins for optogenetics

R. Scott McIsaac, Claire N. Bedbrook, and Frances H. Arnold
Current Opinion in Structural Biology,
10.1016/j.sbi.2015.05.001

Genetically encoded spy ppeptide fusion system to detect plasma membrane-localized proteins in vivo.

Bedbrook, C. N., Kato, M., Kumar, S. R., Lakshmanan, A., Nath, R. D., Sun, F., Sternberg, P. W., Arnold, F. H. and Gradinaru, V.
Chemistry & Biology,
10.1016/j.chembiol.2015.06.020

Directed evolution of Gloeobacter violaceus rhodopsin spectral properties

M. K. M. Engqvist, R. S. McIsaac, P. Dollinger, N. C. Flytzanis, M. Abrams, S. Schor, and F. H. Arnold
Journal of Molecular Biology,
10.1016/j.jmb.2014.06.015

Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures

D. L. Trudeau, T. M. Lee, and F. H. Arnold
BIotechnology and Bioengineering,
10.1002/bit.25308

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons

N. C. Flytzanis, C. N. Bedbrook, H. Chiu, M. K. M. Engqvist, C. Xiao, K Y. Chan, P W. Sternberg, F. H. Arnold, and V. Gradinaru
Nature Communications,
10.1038/ncomms5894

Directed evolution of a far-red fluorescent rhodopsin

R. S. McIsaac, M. K. M. Engqvist, T. Wannier, A. Z. Rosenthal, L. Herwig, N. C. Flytzanis, E. S. Imasheva, J. K. Lanyi, S. P. Balashov, V. Gradinaru, and F. H. Arnold
PNAS,
10.1073/pnas.1413987111

Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination

M. A. Smith, C. N. Bedbrook, T. Wu, and F. H. Arnold
ACS Synth. Biol.,
10.1021/sb400010m

Innovation by homologous recombination

D. L. Trudeau, M. A. Smith, and F. H. Arnold
Curr. Opin. Chem. Biol.,
10.1016/j.cbpa.2013.10.007

Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose

Indira Wu and Frances H. Arnold
Biotechnology and Bioengineering,
10.1002/bit.24864

PNAS Plus: Navigating the protein fitness landscape with Gaussian processes

P. A. Romero, A. Krause, and F. H. Arnold
 Proceedings of the National Academy of Sciences,
10.1073/pnas.1215251110

Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods

R. S. Komor, P. A. Romero, C. B. Xie, and F. H. Arnold
 Protein Engineering Design and Selection,
10.1093/protein/gzs058

Random field model reveals structure of the protein recombinational landscape

P. A. Romero and F. H. Arnold
PLoS Computational Biology,
10.1371/journal.pcbi.1002713

SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis

P. Romero, E. Stone, C. Lamb, L. Chantranupong, A. Krause, A. Miklos, R. Hughes, B. Fechtel, A. Ellington, F. Arnold, and G. Georgiou
ACS Synthetic Biology,
10.1021/sb300014t

Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination

Heinzelman, P., Komor, R., Kanaan, A., Romero, P., Yu, X., Mohler, S., Snow, C., & Arnold, F. H.
Protein Engineering, Design & Selection,
10.1093/protein/gzq063
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