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Douglas Lauffenburger

ICB MIT Program Leader
ICB Systems and Synthetic Biology Co-Leader
Ford Professor
Biological Engineering
Chemical Engineering and Biology
MIT
Phone:
+1 617-252-1629
Email:
lauffen@mit.edu
Website:
Website

Research Focus Areas

Research Interests

Cell, tissue, and biomolecular engineering.  Computational modeling of biological and physiological systems.

National Academies

NAE 2001

News

Displaying 21 - 40 of 44

ICB Supported Publications

In vivo systems biology approaches to chronic immune/inflammatory pathophysiology

Alina Starchenko and Douglas A. Lauffenburger
Current Opinions in Biotechnology,
10.1016/j.copbio.2018.02.006

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis

Jesse Lyons, Douglas K. Brubaker, Phaedra C. Ghazi, Katherine R. Baldwin, Amanda Edwards, Myriam Boukhali, Samantha Dale Strasser, Lucia Suarez-Lopez, Yi-Jang Lin, Vijay Yajnik, Joseph L. Kissil, Wilhelm Haas, Douglas A. Lauffenburger and Kevin M. Haigis
Science Signaling,
10.1126/scisignal.aan3580

On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks

Valdez, J., Cook, C.D., Ahrens, C.C., Wang, A.J., Brown, A., Kumar, M., Stockdale, L., Rothenberg, D., Renggli, K., Gordon, E., Lauffenburger, D., White, F. and Griffith, L.
Biomaterials,
10.1016/j.biomaterials.2017.03.030

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Nicholas, D., Proctor, E.A., Raval, F.M., Ip, B.C., Habib, C., Ritou, E., Grammatopoulos, T.N., Steenkamp, D., Dooms, H., Apovian, C.M., Lauffenburger, D.A. and Nikolajczyk, B.S.
PLoS One,
10.1371/journal.pone.0170975

Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment

Schrier, S.B., Hill, A.S., Plana, D. and Lauffenburger, D.A.
Scientific Reports,
10.1038/srep34942

Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks

Morris, M.K., Clarke, D.C., Osimiri, L.C. and Lauffenburger, D.A.
CPT: Pharmacometrics & Systems Pharmacol,
10.1002/psp4.12104

Th17 cytokines differentiate obesity from obesity-associated Type 2 diabetes and promote TNFα production

Ip, B., Cilfone, N. A., Belkina, A. C., DeFuria, J., Jagannathan-Bogdan, M., Zhu, M., Kuchibhatia, R., McDonnell, M. E., Xiao, Q., Kepler, T.B., Apovian, C. M., Lauffenburger, D. A. and Nikolayczyk, B. S.
Obesity Biology and Integrated Physiology,
10.1002/oby.21243

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Wood, L. B., Winslow, A. R., Proctor, E. A., McGuone, D., Mordes, D. A., Frosch, M. P., Hyman, B. T., Lauffenburger, D. A. and Haigis, K. M.
Scientific Reports,
10.1038/srep16622

Physiome-on-a-chip: The challenge of “scaling” in design, operation, and translation of microphysiological systems

Stokes, C. L., Cirit, M. and Lauffenburger, D. A.
CPT: Pharmacometrics & Systems Pharmacology,
10.1002/psp4.12042

Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells

K. B. Arnold, A. Burgener, K. Birse, L. Romas, L. J. Dunphy, K. Shahabi, M. Abou, G. R. Westmacott, S. McCorrister, J. Kwatampora, B. Nyanga, J. Kimani, L. Masson, L. J. Liebenberg, S. S. Abdool Karim, J. S. Passmore, D. A. Lauffenburger, R. Kaul, and L. R. McKinnon
Mucosal Immunology,
10.1038/mi.2015.51

Identification of drug-specific pathways based on gene expression data: Application to drug induced lung injury

I. N. Melas, T. Sakellaropoulos, F. Iorio, L. G. Alexopoulos, W-Y. Loh, D. A. Lauffenburger, J. Saez-Rodriguez, and J. P. F. Bai
Integrative Biology,
10.1039/C4IB00294F

Prioritisation and network analysis of Crohn’s disease susceptibility genes

D. Muraro, D. A. Lauffenburger, and A. Simmons
PLoS One,
10.1371/journal.pone.0108624

Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation

M. T. Beste, N. Pfäffle-Doyle, E. A. Prentice, S. N. Morris, D. A. Lauffenburger, K. B. Isaacson, and L. G. Griffit
Sci. Transl. Med.,
10.1126/scitranslmed.3007988

Microfluidic probe for single-cell analysis in adherent tissue culture

A. Sarkar, S. Kolitz, D. A. Lauffenburger, and J. Han
Nat. Commun.,
10.1038/ncomms4421

Qualitatively different T cell phenotypic responses are unified by identical dependences on receptor signal strength and duration

A. Arneja, H. Johnson, L. Gabrovsek, D. A. Lauffenburger, and F. M. White
J. Immunol.,
10.4049/jimmunol.1302291

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α

K. S. Lau, S. B. Schrier, J. Gierut, J. Lyons, D. A Lauffenburger, and K. M. Haigis
Integr. Biol.,
10.1039/c3ib40062j

Normalization and Statistical Analysis of Multiplexed Bead-based Immunoassay Data Using Mixed-effects Modeling

David C. Clarke, Melody K. Morris, and Douglas A. Lauffenburger
Molecular & Cellular Proteomics,
10.1074/mcp.M112.018655

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

A. Mitsos, I. N. Melas, M. K. Morris, J. Saez-Rodriguez, D. A. Lauffenburger, and L. G. Alexopoulos
 PLoS ONE,
10.1371/journal.pone.0050085

CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms

C. Terfve, T. Cokelaer, D. Henriques, A. MacNamara, E. Goncalves, M. K. Morris, M. van Iersel, D. A. Lauffenburger, and J. Saez-Rodriguez
BMC Systems Biology,
10.1186/1752-0509-6-133

Measurement and Modeling of Signaling at the Single-Cell Level

S. E. Kolitz and D. A. Lauffenburger
 Biochemistry,
10.1021/bi300846p
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