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Douglas Lauffenburger

ICB MIT Program Leader
ICB Systems and Synthetic Biology Co-Leader
Ford Professor
Biological Engineering
Chemical Engineering and Biology
MIT
Phone:
+1 617-252-1629
Email:
lauffen@mit.edu
Website:
Website

Research Focus Areas

Research Interests

Cell, tissue, and biomolecular engineering.  Computational modeling of biological and physiological systems.

National Academies

NAE 2001

News

Displaying 1 - 20 of 44

ICB Supported Publications

AutoTransOP: Translating Omics Signatures without Orthologue Requirements using Deep Learning

Nikolaos Meimetis, Krista M. Pullen, Daniel Y. Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, and Douglas A. Lauffenburger
npj Systems Biology and Applications,
10.1038/s41540-024-00341-9

Autoencoder Model for Translating Omics Signatures

Nikolaos Meimetis, Krista M. Pullen, Daniel Y. Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A. Lauffenburger
bioRxiv,
10.1101/2023.06.08.544243

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.

Alicia R. Berard, Douglas K. Brubaker, Kenzie Birse, Alana Lamont, Romel D. Mackelprang, Laura Noël-Romas, Michelle Perner, Xuanlin Hou, Elizabeth Irungu, Nelly Mugo, Samantha Knodel, Timothy R. Muwonge, Elly Katabira, Sean M. Hughes, Claire Levy, Fernanda L. Calienes, Douglas A. Lauffenburger, Jared M. Baeten, Connie Celum, Florian Hladik, Jairam Lingappa, Adam D. Burgener
Cell Reports,
10.1016/j.celrep.2023.112474

Screening for CD19-specific chimeric antigen receptors with enhanced signaling via a barcoded library of intracellular domains

Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann and Michael E. Birnbaum
Nature Biomedical Engineering,
10.1038/s41551-022-00896-0

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf,
Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger, and Kevin M. Haigis.
iScience,
10.1016/j.isci.2021.103406

Translatable pathways classification (TransPath-C) for inferring processes germane to human biology from animal studies data: example application in neurobiology

Molly J Carroll, Natàlia Garcia-Reyero, Edward J Perkins, Douglas A Lauffenburger
Integrative Biology,
10.1093/intbio/zyab016

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Meelim J. Lee, Chuangqi Wang, Molly J. Carroll, Douglas K. Brubaker, Bradley T. Hyman and Douglas A. Lauffenburger
Frontiers in Neuroscience,
10.3389/fnins.2021.727784

Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease

Nader Morshed, Meelim Lee, Felicia H. Rodriguez, Douglas A. Lauffenburger, Diego Mastroeni, Forest White
Nature Aging,
10.1038/s43587-021-00071-1

Cell surface integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3

Alina Starchenko, Ramona Graves-Deal, Douglas Brubaker, Cunxi Li, Yuping Yang, Bhuminder Singh, Robert J Coffey, Douglas A Lauffenburger
Integrative Biology,
10.1093/intbio/zyab009

Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury in Vitro

Wen Li Kelly Chen, Emily Suter, Hikaru Miyazaki, Jason Velazquez, Douglas A. Lauffenburger, Linda G. Griffith, and Rebecca L. Carrier
ACS Infectious Diseases,
10.1021/acsinfecdis.0c00762

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

M. Trapecar, E. Wogram, D. Svoboda, C. Communal, A. Omer, T. Lungjangwa,
P. Sphabmixay, J. Velazquez, K. Schneider, C. W. Wright, S. Mildrum, A. Hendricks, S. Levine, J. Muffat,
M. J. Lee, D. A. Lauffenburger, D. Trumper, R. Jaenisch, L. G. Griffith
Science Advances,
10.1126/sciadv.abd1707

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease

Douglas K. Brubaker, Manu P. Kumar, Evan L. Chiswick, Cecil Gregg, Alina Starchenko, Paige N. Vega, Austin N. Southard-Smith, Alan J. Simmons, Elizabeth A. Scoville, Lori A. Coburn, Keith T. Wilson, Ken S. Lau, Douglas A. Lauffenburger
Science Signaling,
10.1126/scisignal.aay3258

Coagulopathy signature precedes and predicts severity of endorgan heat stroke pathology in a mouse model

Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon
Journal of Thrombosis and Haemostasis,
10.1111/jth.14875

Translating preclinical models to humans

Douglas K. Brubaker, Douglas A. Lauffenburger
Science,
10.1126/science.aay8086

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A.Nicholas, Elizabeth A.Proctor, Madhur Agrawal, Anna C.Belkina, Stephen C.Van Nostrand, Leena Panneerseelan-Bharath, Albert R.Jones, Forum Raval, Blanche C., Min Zhu, Jose M.Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G.Sullivan, Barbara E.Corkey, Caroline M.Apovian, Philip A.Kern, Douglas A. Lauffenburger, Barbara S.Nikolajczyk
Cell Metabolism,
10.1016/j.cmet.2019.07.004

Computational translation of genomic responses from experimental model systems to humans

Douglas K. Brubaker, Elizabeth A. Proctor, Kevin M. Haigis, Douglas A. Lauffenburger
PLOS Computational Biology,
10.1371/journal.pcbi.1006286

Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

Allison M. Claas, Lyla Atta, Simon Gordonov, Aaron S. Meyer, and Douglas A. Lauffenburger
Cellular and Molecular Bioengineering,

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

Douglas S. Jones, Anne P. Jenney, Brian A. Joughin, Peter K. Sorger, and Douglas A. Lauffenburger
Science Signaling,
10.1126/scisignal.aal1601

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function

Christi D. Cook, Abby S. Hill, Margaret Guo, Linda Stockdale, Julia P. Papps, Keith B. Isaacson, Douglas A. Lauffenburger and Linda G. Griffith
Integrative Biology,
10.1039/C6IB00245E

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

Jesse Lyons, Phaedra C. Ghazi, Alina Starchenko, Alessio Tovaglieri, Katherine R. Baldwin, Emily J. Poulin, Jessica J. Gierut, Casie Genetti, Vijay Yajnik, David T. Breault, Douglas A. Lauffenburger and Kevin M. Haigis
PLOS Biology,
10.1371/journal.pbio.2002417
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